Strategies That Facilitate Extraction-Free SARS-CoV-2 Nucleic Acid Amplification Tests

Strategies That Facilitate Extraction-Free SARS-CoV-2 Nucleic Acid Amplification Tests

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The COVID-19 pandemic has resulted in an unprecedented global demand for in vitro diagnostic reagents.Supply shortages and hoarding have impacted testing Sugar Substitutes capacity which has led to inefficient COVID-19 case identification and transmission control, predominantly in developing countries.Traditionally, RNA extraction is a prerequisite for conducting SARS-CoV-2 nucleic acid amplification tests (NAAT); however, simplified methods of sample processing have been successful at bypassing typical nucleic acid extraction steps, enabling extraction-free SARS-CoV-2 NAAT workflows.

These methods involve chemical and physical approaches that are inexpensive and easily accessible Hockey Protective - Pants - Intermediate alternatives to overcome extraction kit supply shortages, while offering acceptable test performance.Here we provide an overview of three main sample preparation strategies that have been shown to facilitate extraction-free SARS-CoV-2 NAATs.